Our Science

Medicine reacts. We test for answers.

Most labs tell you whether you're sick. Zaro tells you what's developing, what's at the root, and how your biology is aging, so you can act years before a diagnosis.

The Cascade Model

No other testing platform offers all three tiers of the cascade. Each level answers a fundamentally different question about your health.

SurfaceHas something already gone wrong?
$14961+ markers
SignalIs something developing?
$29988+ markers
SourceWhat root causes?
$59995+ markers
Surface → Signal → Source: deeper understanding at each level

Has something already gone wrong?

Surface

$149
61 biomarkers55 measured · 6 calculated10 lab draws
Get Surface

Body Systems Covered

Heart & Vessels
Metabolic / Liver
Blood Health
Thyroid
Kidneys
Nutrients
Hormones
Brain & Cognition
Immune
Longevity
Cancer Signals
Heavy Metals

Grayed systems available via add-ons

The Science

Surface testing captures what has already crossed clinical thresholds. The markers in this panel are what standard medicine looks at during a routine physical, but most people never get a full panel done. These are the red flags that, if caught early, prevent the most common causes of preventable death: heart disease, type 2 diabetes, thyroid dysfunction, and anemia. Surface is the foundation every adult should have at minimum once a year.

Who It's For

Anyone who has never had comprehensive bloodwork done, adults over 25 who want a baseline, or anyone who has not had labs in over two years. A great starting point for first-time Zaro users.

Biomarkers Included

Metabolic Core

  • Comprehensive Metabolic Panel (CMP) — Glucose, BUN, Creatinine, eGFR, BUN/Cr Ratio, Sodium, Potassium, Chloride, CO₂, Calcium, Total Protein, Albumin, Total Bilirubin, ALP, AST, ALT (14 values)
  • CBC with Differential — WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelets, Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils + absolute counts (22 values)
  • HbA1c (Glycated Hemoglobin)
  • Fasting Insulin
  • Uric Acid

Heart & Lipids

  • Total Cholesterol
  • LDL Cholesterol
  • HDL Cholesterol
  • Triglycerides
  • Non-HDL Cholesterol (calculated)
  • hs-CRP (High-Sensitivity C-Reactive Protein)

Thyroid

  • TSH (Thyroid Stimulating Hormone)

Urinalysis

  • Complete Urinalysis with Microscopy — Color, Clarity, Specific Gravity, pH, Protein, Glucose, Ketones, Blood, Bilirubin, Urobilinogen, Nitrites, Leukocyte Esterase, WBC/hpf, RBC/hpf (14 values)

Advanced Cardiometabolic

  • ApoB (Apolipoprotein B)
61 biomarkers from 10 distinct lab draws
CMP ×14 + CBC with differential ×22 — the full metabolic picture
ApoB — the cardiovascular risk marker most annual physicals skip
Urinalysis with microscopy — kidney and metabolic snapshot
FSA/HSA eligible
Results in 5–7 business days
Most Popular

Is something developing?

Signal

$299
88 biomarkers76 measured · 12 calculated21 lab draws
Get Signal
IncludesEverything in Surface: all 61 biomarkers from 10 lab draws are included in this panel.

Body Systems Covered

Heart & Vessels
Metabolic / Liver
Blood Health
Thyroid
Kidneys
Nutrients
Hormones
Brain & Cognition
Immune
Longevity
Cancer Signals
Heavy Metals

Grayed systems available via add-ons

The Science

Signal markers are the early warning system of modern preventive medicine. While Surface markers respond to disease that has already developed, Signal markers detect the physiological conditions that lead to disease, years or even decades before clinical symptoms appear. Elevated ApoB predicts cardiovascular events long before LDL changes. Fasting insulin rises 10–15 years before HbA1c signals pre-diabetes. Elevated hsCRP identifies systemic inflammation that silently damages organs. Signal is where the real prevention happens.

Who It's For

Health-optimizers, athletes, anyone with a family history of cardiovascular disease or metabolic dysfunction, people in their 30s and 40s who want to get ahead of risks, and anyone who has already done Surface and wants to go deeper.

What Signal Adds

Nutrients

  • Vitamin D (25-OH)
  • Vitamin B12
  • Ferritin
  • Iron & TIBC (Iron, Total Iron-Binding Capacity, % Saturation)
  • Magnesium

Advanced Cardiometabolic

  • Lipoprotein(a) — Lp(a)
  • LDL Particle Size & Fractionation (NMR) — LDL-P, Small LDL-P, HDL-P, LDL Size, Large HDL-P (5 values)
  • Homocysteine
  • Omega-3 Index (EPA%, DHA%, Total Index)

Extended Thyroid

  • Free T3 (Free Triiodothyronine)
  • Free T4 (Free Thyroxine)

Hormones

  • Testosterone (Total)
  • Testosterone (Free)
  • SHBG (Sex Hormone-Binding Globulin)
  • DHEA-S (Dehydroepiandrosterone Sulfate)
  • Estradiol (E2)
  • FSH (Follicle-Stimulating Hormone)
  • LH (Luteinizing Hormone)
  • Progesterone

Metabolic Depth

  • Folate (Serum)
  • Zinc
Everything in Surface (61 biomarkers) + 27 additional markers
88 total biomarkers from 21 lab draws
NMR lipid fractionation — identifies dangerous LDL particle patterns standard lipid panels miss
Full hormone panel: testosterone, estradiol, FSH, LH, SHBG, DHEA-S
Omega-3 index — over 80% of people are deficient and don't know
Lp(a) — genetic cardiovascular risk present in 20% of the population
FSA/HSA eligible
Results in 5–7 business days
Most Comprehensive

What root causes?

Source

$599
95 biomarkers82 measured · 13 calculated27 lab draws
Get Source
IncludesEverything in Signal: all 88 biomarkers from 21 lab draws are included in this panel.

Body Systems Covered

Heart & Vessels
Metabolic / Liver
Blood Health
Thyroid
Kidneys
Nutrients
Hormones
Brain & Cognition
Immune
Longevity
Cancer Signals
Heavy Metals

Grayed systems available via add-ons

The Science

Source reaches the root causes that Signal does not capture: the upstream hormonal imbalances, toxic inflammatory loads, cellular aging markers, and longevity signals that determine how your body ages. PhenoAge (biological age from blood) and the AHA PREVENT heart age model give you two independent scores of how your biology is aging relative to your chronological age, the most powerful feedback loop available in consumer health today. Source also includes the deep hormonal, adrenal, and nutritional panels that explain why your body is performing the way it is.

Who It's For

Longevity-focused individuals, those with chronic fatigue, hormonal symptoms, or unresolved health issues, people who have completed Signal and want root causes, and anyone seriously committed to optimizing how they age.

What Source Adds

Advanced Cardiometabolic

  • Fibrinogen (coagulation and inflammation risk)

Advanced Kidney

  • Microalbumin/Creatinine Ratio (early kidney damage detection, 2 values)

Extended Thyroid

  • TPO Antibodies (Thyroid Peroxidase — autoimmune thyroid screen)
  • Thyroglobulin Antibodies (autoimmune thyroid screen)

Metabolic Depth

  • HOMA-IR (Insulin Resistance Index — calculated from fasting glucose + insulin)

Cognitive Risk

  • Vitamin B1 (Thiamine)
Everything in Signal (88 biomarkers) + 7 additional markers
95 total biomarkers from 27 lab draws
TPO + Thyroglobulin antibodies — detects autoimmune thyroid disease (Hashimoto's, Graves')
Fibrinogen — independent cardiovascular risk factor beyond LDL
Microalbumin/creatinine ratio — earliest detectable sign of kidney stress
HOMA-IR — calculated insulin resistance score revealing pre-diabetes risk years earlier than HbA1c
Unlocks Biological Age (PhenoAge) and Heart Age (AHA PREVENT) scores
FSA/HSA eligible
Results in 5–7 business days
Available Add-Ons

Extend any panel

Add specialized panels to any Surface, Signal, or Source order. Each add-on targets a specific risk area with markers that go beyond the core cascade.

Autoimmune Screen

2 markers

Broad screen for systemic autoimmune activity. Appropriate for unexplained fatigue, joint pain, or family history of autoimmune disease.

  • ANA with Reflex (Antinuclear Antibody — reflex to titer and pattern if positive)
  • ESR (Erythrocyte Sedimentation Rate)

Cancer Screening

2 markers

General cancer signal markers used alongside clinical screening, not as standalone diagnostics.

  • CEA (Carcinoembryonic Antigen)
  • AFP (Alpha-Fetoprotein)

Men's Cancer Screening

1 marker

Prostate-specific antigen screening for men. Recommended starting at age 40–45 for those with family history, or 50 for average risk.

  • PSA (Prostate-Specific Antigen — Total)

Women's Cancer Screening

1 marker

Ovarian cancer antigen marker used as a monitoring tool, particularly for those with family history or known risk factors.

  • CA-125 (Cancer Antigen 125)

Cognitive Risk Panel

2 markers

Advanced genetic and protein markers for Alzheimer's and neurodegeneration risk. These are the markers longevity physicians order for patients with family history of cognitive decline.

  • ApoE Genotype (APOE ε4 allele — strongest genetic risk factor for Alzheimer's)
  • p-tau217 (Phosphorylated Tau 217 — early blood biomarker for Alzheimer's pathology)

Heavy Metals Expansion

2 markers

Blood levels of the two most common toxic metal exposures. Relevant for those with occupational exposure, old housing, or fish-heavy diets.

  • Lead (Blood)
  • Mercury (Blood)

Advanced Panel

6 markers

Deep longevity, inflammation, and kidney markers used in cutting-edge preventive medicine and biological age research.

  • IGF-1 (Insulin-Like Growth Factor 1)
  • IL-6 (Interleukin-6 — inflammatory cytokine)
  • Oxidized LDL (oxidative stress and atherosclerosis)
  • Cortisol (AM — adrenal function)
  • GGT (Gamma-Glutamyl Transferase — liver stress and alcohol metabolism)
  • Cystatin C (more accurate eGFR than creatinine alone)

Two ages. One clock.

Zaro calculates your Biological Age (PhenoAge), reflecting how old your body actually is based on blood chemistry, and your Heart Age using the AHA PREVENT model. Is your biology aging faster or slower than your birthday suggests?

Chronological Age

38
335 YRS YOUNGER

Biological Age

PhenoAge Model

413 YRS OLDER

Heart Age

AHA PREVENT

Example output · your results will reflect your actual blood data

Zaro Score

A living health score, built on three pillars

Zaro synthesizes bloodwork, wearable signals, and lifestyle into a single score out of 100. It updates continuously and adapts to whatever data you have, no wearable required to get started.

78/ 100Strong

Score Bands

Optimal90–100
Strong75–89
Moderate60–74
At-Risk40–59
Critical<40
Score out of 10030-day trendBiological age
Layer 1 · From your bloodwork
Clinical Foundation
PhenoAge10-yr CV Risk30-yr CV Risk
Layer 2 · From Apple Health & wearables
Daily Performance
VO2 MaxHeart RateHRVSleep
Layer 3 · From weekly check-ins
Lifestyle
ExerciseNutritionStressHabits

Adaptive weighting

Score adapts automatically as you add data

Full data

Labs + wearable + lifestyle

ClinicalPerformanceLifestyle

No wearable

Labs re-weighted with lifestyle

ClinicalLifestyle

Labs only

Biomarker Score shown

Clinical Foundation

Start knowing your body.

Choose a panel, schedule your blood draw, and get answers that actually explain what is happening inside your body.